Key result
Percutaneous intrapericardial bFGF delivery safely produces functionally significant myocardial angiogenesis via subxyphoid access.
The pericardial space offers a viable, safe, and reliable route for delivering angiogenic agents like bFGF directly to the heart via percutaneous subxyphoid access.
Supports safe subxyphoid intrapericardial bFGF delivery for angiogenesis; hypothesis-generating and requires randomized trials before clinical use.
In this manuscript, we describe the potential role of the pericardial space as a drug delivery reservoir to administer angiogenic agents to the heart resulting in functionally significant angiogenesis with single bolus basic fibroblast growth factor (bFGF) delivery. We also describe a percutaneous subxyphoid pericardial access technique that is safe, rapid, and reliable.
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Laham et al. (1999) studied this question. Percutaneous intrapericardial delivery of basic fibroblast growth factor produces functionally significant myocardial angiogenesis via a safe and rapid subxyphoid access technique.
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