August 1, 1996AJP Heart and Circulatory Physiology
Enhanced microvascular relaxations to VEGF and bFGF in chronically ischemic porcine myocardium
Population
7 Yorkshire pigs with ameroid constrictors placed on the proximal left circumflex artery to induce chronic…
Comparison
Vascular endothelial growth factor and basic… vs Microvessels from the normally perfused left…
Design
Preclinical
Follow-up
7 to 9 weeks
Authors
Discussion
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Implication
Chronic ischemia may enhance microvascular angiogenic responses in porcine models; leaves open translation to human coronary disease or therapy.
Structured PICO
P
Population
7 Yorkshire pigs with ameroid constrictors placed on the proximal left circumflex (LCX) artery to induce chronic ischemia
I
Intervention
Vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF)
C
Comparator
Microvessels from the normally perfused left anterior descending (LAD) region
O
Outcome
Microvascular relaxations to VEGF and bFGFsurrogate
Chronic ischemia enhances microvascular relaxations to VEGF and bFGF in porcine myocardium, likely due to increased gene expression of their respective tyrosine kinase receptors.
Cite This Study
Sellke et al. (1996) studied this question.