Key result
Aortic valve-sparing root reconstruction is linked to lower late mortality versus composite graft-valve replacement.
Why the study?
Does aortic valve-sparing operation improve survival and reduce complications compared to composite graft-valve replacement in patients undergoing aortic root reconstruction?
Cohort (n=324)
Does aortic valve-sparing operation improve survival and reduce complications compared to composite graft-valve replacement in patients undergoing aortic root reconstruction?
Absolute Event Rate: 4.9% vs 6.7%
p-value: p=ns
Aortic root reconstruction with valve-sparing techniques is associated with lower late mortality and fewer bleeding events compared to composite graft-valve replacement.
Valve-sparing reconstruction was associated with lower late mortality; leaves open whether it should be preferred over composite replacement pending randomized data.
OBJECTIVE: To compare the results of the root reconstruction with the aortic valve-sparing operation versus composite graft-valve replacement. METHODS: From January 2002 to October 2013, 324 patients underwent aortic root reconstruction. They were 263 composite graft-valve replacement and 61 aortic valve-sparing operation (43 reimplantation and 18 remodeling). Twenty-six percent of the patients were NYHA functional class III and IV; 9.6% had Marfan syndrome, and 12% had bicuspid aortic valve. There was a predominance of aneurysms over dissections (81% vs. 19%), with 7% being acute dissections. The complete follow-up of 100% of the patients was performed with median follow-up time of 902 days for patients undergoing composite graft-valve replacement and 1492 for those undergoing aortic valve-sparing operation. RESULTS: In-hospital mortality was 6.7% and 4.9%, respectively for composite graft-valve replacement and aortic valve-sparing operation (ns). During the late follow-up period, there was 0% moderate and 15.4% severe aortic regurgitation, and NYHA functional class I and II were 89.4% and 94%, respectively for composite graft-valve replacement and aortic valve-sparing operation (ns). Root reconstruction with aortic valve-sparing operation showed lower late mortality (P=0.001) and lower bleeding complications (P=0.006). There was no difference for thromboembolism, endocarditis, and need of reoperation. CONCLUSION: The aortic root reconstruction with preservation of the valve should be the operation being performed for presenting lower late mortality and survival free of bleeding events.
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Lamana et al. (2015) conducted a cohort in Aortic root disease (n=324). Aortic valve-sparing operation vs. Composite graft-valve replacement was evaluated on In-hospital mortality (p=ns). Aortic valve-sparing root reconstruction was associated with similar in-hospital mortality (4.9% vs 6.7%) but significantly lower late mortality (P=0.001) compared to composite graft-valve replacement.
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