Key result
Anti-mitochondrial M2 antibodies linked to eosinophilic myocarditis and myositis, suggesting mitochondrial damage triggers inflammation.
Why the study?
The mechanism underlying eosinophilic myocarditis associated with anti-mitochondrial M2 antibodies and its link to myocarditis onset was unclear.
Population
1 68-year-old woman with eosinophilic myocarditis and increased eosinophils
Design
Case report
Authors
Loading...
May warrant anti-M2 antibody testing in eosinophilic myocarditis with myositis; hypothesis-generating for mitochondrial PDC-E2 as inflammatory trigger.
Case Report (n=1)
Anti-mitochondrial M2 antibodies may drive eosinophilic myocarditis and myositis via immune reactions against PDC-E2 released from damaged mitochondria.
Saito et al. (2018) conducted a case report in Eosinophilic myocarditis and myositis (n=1). Anti-mitochondrial M2 antibodies was evaluated. In a 68-year-old woman, eosinophilic myocarditis and subsequent myositis were associated with anti-mitochondrial M2 antibodies, suggesting mitochondrial damage triggers inflammatory activation.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: