Key result
Recombinant rN and rH/Nh proteins yield neutralizing antibodies at slightly lower titers than native antigen.
Recombinant proteins rN and rH/Nh of the measles virus strain NovO/96 elicit neutralizing antibodies in mice, with titers slightly lower than the native antigen.
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Recombinant measles antigens merit further preclinical testing; leaves open human immunogenicity, safety, and efficacy trials.
Kulak et al. (2008) studied Measles. Recombinant proteins rN and rH/Nh vs. Native antigen was evaluated on Virus neutralization titer. Immunization with recombinant proteins rN and rH/Nh generated neutralizing antibodies with titers of 1:13.5 and 1:22.9, compared to 1:25.7 for the native antigen.
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