Key result
AVR with St. Jude mechanical valves shows ~87% freedom from valve-related death at 20 years.
Why the study?
Mechanical valves remain the standard choice for AVR, especially in younger patients, but very long-term outcomes in Japanese patients were not well established.
Cohort (n=801)
Yes
St. Jude Medical mechanical valves provide excellent 20-year durability with very low rates of reoperation and acceptable rates of bleeding and thromboembolism, supporting their use in younger patients.
Answers are grounded in this paper and cite their sources.
May support SJM mechanical AVR for select younger patients; leaves open need for contemporary randomized confirmation.
BACKGROUND: Bioprostheses have become increasingly popular for aortic valve replacement (AVR) in recent years, but mechanical valves are still the standard choice, especially for younger patients. The aim of this study was to assess the very long-term outcomes in Japanese patients who underwent AVR with St. Jude Medical (SJM) mechanical valves. METHODS AND RESULTS: From 1991 to 2001, a total of 816 patients underwent AVR with SJM mechanical valves in 5 hospitals. Of these, 801 patients (mean age, 58.3±11.7 years) were analyzed in this study. There were 24 in-hospital deaths (3.0%). Mean follow-up duration was 11.6±6.7 years and the 10-year follow-up rate was 84.1%. Freedom from valve-related death at 5, 10, 15, and 20 years was 96.2%, 92.7%, 88.8%, and 86.6%, respectively. The linearized ratio of major bleeding events and thromboembolic events was 1.1% per patient-year and 1.0% per patient-year, respectively. Freedom from reoperation for the aortic prosthesis was 98.0% and 94.8% at 10 and 20 years, respectively. CONCLUSIONS: The SJM mechanical valve provided excellent long-term freedom from valve-related death and reoperation in patients undergoing AVR. Therefore, this valve should be recommended to younger patients who wish to avoid reoperation.
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Minakata et al. (2015) conducted a cohort in Aortic valve disease requiring replacement (n=801). St. Jude Medical mechanical valves for aortic valve replacement was evaluated on Freedom from valve-related death at 20 years. Aortic valve replacement with St. Jude Medical mechanical valves in Japanese patients demonstrated excellent long-term durability, with freedom from valve-related death and reoperation at 20 years of 86.6% and 94.8%, respectively.
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