Key result
Bone-cardiovascular endocrine crosstalk highlights novel targets for cardiovascular disease prevention and treatment.
Why the study?
The biological properties of the bone-heart axis and its role in the pathogenesis and susceptibility to cardiovascular diseases remain to be elucidated.
The bone-heart axis represents a novel non-canonical cardiovascular risk factor and potential target for precision medicine in cardiovascular disease.
Cardiovascular diseases (CVDs) cause about 30% of deaths worldwide, increasing social and economic burden in our societies. Although the treatment of the canonical cardiovascular risk factors has reduced the impact of CVDs on morbidity and mortality in the past few years, they continue to represent a major health problem. The definition of the biological properties of the bone-heart axis has led to new insights in the pathogenesis of CVDs; hence, the aim of this review is to try to elucidate the role of this axis on the susceptibility to CVDs. There is evidence that the bone interacts with extra-skeletal organs, including the cardiovascular system, through its endocrine functions. Clinical and experimental data strongly indicate that the interplay between the bone and the cardiovascular system represents a future tool for the prevention, diagnosis and treatment of CVDs. The identification of these non-canonical cardiovascular risk factors could prompt pharmacological research towards new target therapy aimed at precision medicine.
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Vergatti et al. (2025) conducted a review in Cardiovascular diseases. Bone-heart axis was evaluated. The interplay between the bone and the cardiovascular system through endocrine functions represents a potential future tool for the prevention, diagnosis, and treatment of cardiovascular diseases.
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