Key result
Male gender is linked to ~8-fold greater myocardial fibrosis and lower LVEF in Chagas disease.
Why the study?
A male-related higher cardiovascular morbidity and mortality in patients with Chagas' heart disease has been reported, motivating investigation of gender differences in myocardial damage assessed by CMR.
Does male gender correlate with greater myocardial damage assessed by CMR in patients with Chagas' heart disease?
Population
62 seropositive Chagas' heart disease patients referred to CMR with low probability of significant coronary artery disease
Comparison
Male gender vs female gender
Design
Retrospective cohort study
Authors
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May support sex-stratified monitoring in Chagas cardiomyopathy; leaves open whether fibrosis mediates worse male outcomes.
Cross-Sectional (n=62)
No
Does male gender correlate with greater myocardial damage assessed by CMR in patients with Chagas' heart disease?
Absolute Event Rate: 19% vs 2.4%
p-value: p=<0.001
Male patients with Chagas' heart disease exhibit significantly greater myocardial fibrosis and lower LV ejection fraction on CMR compared to females, which may explain their poorer prognosis.
Assunção et al. (2016) conducted a cross-sectional in Chagas' heart disease (n=62). Male gender vs. Female gender was evaluated on Myocardial fibrosis amount (grams) (p=<0.001). Male gender was associated with significantly greater myocardial fibrosis (median 19.0g vs 2.4g) and lower left ventricular ejection fraction (37% vs 58%) compared to females with Chagas' heart disease.
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