Key result
Fibroscan-detected non-alcoholic hepatic steatosis is strongly linked to coronary artery atherosclerosis.
Why the study?
Non-alcoholic hepatic steatosis is associated with increased CAD incidence, but assessing its frequency using Fibroscan alongside coronary CT angiography needed evaluation.
Is hepatic steatosis detected by Fibroscan correlated with coronary artery disease detected by CT angiography in patients with NAFLD?
Cross-Sectional (n=60)
Is hepatic steatosis detected by Fibroscan correlated with coronary artery disease detected by CT angiography in patients with NAFLD?
Hepatic steatosis detected by Fibroscan may serve as a relevant non-invasive predictor of coronary artery disease.
Steatosis on Fibroscan may flag higher CAD likelihood in NAFLD; leaves open incremental predictive value beyond standard risk factors.
Background: Non-alcoholic hepatic steatosis, considered to be the hepatic manifestation of Metabolic Syndrome (MS), is the commonest liver disease in industrialized countries and it is associated with increased incidence for Coronary Artery Disease (CAD).A high percentage of hepatic steatosis was detected in patients who examined by invasive coronary angiography with increased incidence of relevant coronary artery disease in patients with fatty liverin comparison to those who did not have signs of lipid accumulation in liver on ultrasound.Aim of Study: This study aims to assess the frequency of non-alcoholic fatty liver diseases in coronary heart disease patients by using a new diagnostic tool: TE (Fibroscan) and coronary CT angiography.Patient and Methods: A total number of 60 patients suffered from Non-Alcoholic Fatty Liver Disease (NAFLD) to be examined by fibroscan examination with CAP parameter and then computed tomography coronaries angiography by using agaston score.Results: The age of the patients ranged from (32-72) years with mean age of 52 years, 34 male patients (56.7%) and 26 female patients (43.3%), in this study there were 28 patients suffered from hypertension, 28 patients suffered from DM, 20 patients were smokers, 18 patients were obese and 6 patients had no risk factors with overlap of the risk factors. In this study there were 18 patients did not suffer from coronary stenosis, 10 patients suffered from minimal stenosis, 6 patients suffered from mild stenosis, 16 patients suffered from moderate stenosis and 10 patients suffered from severe stenosis according to Agaston score. According to CAP parameter in this study there were 12 patients suffered from mild steatosis, 16 patients suffered from moderate steatosis, 28 patients suffered from severe steatosis and 4 patients did not suffered from steatosis.Conclusions: The fibroscan is the best non-invasive technique in diagnosis of the hepatic steatosis. The multi-detector CT coronary angiography is a good method in diag-nosis of the coronaries diseases and stenosis provide excellent diagnostic results. Nonalcoholic hepatic steatosis that deter-mined by fibroscan, is strongly correlated with coronary artery atherosclerosis therefore, be a relevant predictor of coronary-diseases.
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NAGA et al. (2019) conducted a cross-sectional in Non-Alcoholic Fatty Liver Disease (NAFLD) and Coronary Heart Disease (n=60). Non-alcoholic hepatic steatosis was evaluated on Frequency and severity of coronary stenosis and hepatic steatosis. Non-alcoholic hepatic steatosis detected by Fibroscan was strongly correlated with coronary artery atherosclerosis in a cohort of 60 patients, where 42 (70%) exhibited coronary stenosis.
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