Key result
Pre-radiation hesperidin reduces radiation-induced heart inflammation by ~100% and decreases vascular plaque in rats.
Why the study?
The heart is the major dose-limiting organ for radiotherapy of mediastinal malignant tumors, prompting investigation into the radioprotective effects of hesperidin following localized irradiation.
Does Hesperidin reduce radiation-induced cardiac injury and troponin-1 elevation in male rats?
Does Hesperidin reduce radiation-induced cardiac injury and troponin-1 elevation in male rats?
Absolute Event Rate: 0% vs 80%
p-value: p=0.001
Hesperidin administration prior to radiotherapy may reduce radiation-induced cardiac injury and troponin-1 elevation in a preclinical rat model.
BACKGROUND: The heart is the major dose-limiting organ for radiotherapy of malignant tumor in the mediastanal region. OBJECTIVE: This study aims to investigate the radio protective effects of Hesperidin (HES) as a natural flavonoid after localized irradiation of the rat's mediastinum region. MATERIAL AND METHODS: In this experimental study, we divided sixty male rats into 4 groups (n=15). First group: Sham which received PBS; second group: Hesperidin only (100 mg/kg/day orally) for one week; third group: Radiation that received single dose of 20 Gy gamma radiation using Co-60 unit and the forth group: Radiation+HES that underwent the same dose of radiation and received HES for 7 days prior irradiation. Each group was divided in two branches. Early sampling from subgroup one was done 4-6 hours after irradiation to determine troponin-1 level changes. Rats of second subgroups were killed 56 days after irradiation for histopathological evidence. RESULTS: In radiation group, troponin -1 serum level had a significant increase in comparison with sham group (P<0.05). Histopathological evaluation of second subgroup showed there was a significant difference between sham and radiation group in some parameters. Inflammation (p=0.008), pericardial effusion (P=0.001), and vascular plaque (P=0.001) had an increase in the irradiation group. Oral administration of hesperidin significantly decreased all the above factors when was compared with irradiation group (P>0.016). CONCLUSION: Oral administration of Hesperidine for seven days prior radiotherapy may decrease troponin-1 and cardiac injury due to radiation.
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A 2021 study studied Radiation-induced heart injury (n=60). Hesperidin vs. Radiation only (20 Gy) was evaluated on Heart tissue inflammation 8 weeks post-irradiation (p=0.001). Oral administration of hesperidin for seven days prior to radiotherapy significantly decreased radiation-induced heart tissue inflammation, pericardial effusion, and vascular plaque in rats.
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