Key result
Hemorrhagic enteritis virus spares poults under three weeks old while older susceptible survivors resist challenge.
Why the study?
The infectivity and immune response to turkey hemorrhagic enteritis virus in poults with no maternal antibody and in bursectomized or virus-injected turkeys were not fully understood.
Age and bursectomy influence the susceptibility and immune response of turkeys to hemorrhagic enteritis virus.
Age-dependent resistance in turkey poults leaves open optimal timing for vaccination or intervention; hypothesis-generating for avian immune maturation studies.
The infectivity of turkey hemorrhagic enteritis (HE) virus was studied in poults with no detectable maternal antibody and in turkeys bursectomized or injected with killed-virus preparations. Poults less than three weeks old were not infected by hemorrhagic enteritis virus, and survivors were susceptible to challenge at the age of eight weeks. Three- and four-week-old poults were susceptible to HE, and survivors resisted challenge. Bursectomy partially interfered with the immune response but did not alter the course of the disease, and survivors were resistant to challenge. Injections of spleen suspension containing 1% formalin produced antibody in only two of six turkeys. Three of the four poults without detectable antibody resisted challenge.
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Beasley et al. (1978) studied Hemorrhagic enteritis (HE) virus infection. Hemorrhagic enteritis virus exposure, bursectomy, or killed-virus preparations was evaluated on Infectivity and immune response. Poults less than three weeks old were not infected by hemorrhagic enteritis virus, while three- and four-week-old poults were susceptible and survivors resisted challenge.
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