Key result
Adipose tissue and its microenvironment are linked to colorectal cancer development and progression.
Why the study?
Understanding the pathogenetic mechanisms of adipose tissue influence on colorectal carcinogenesis may assist in preventing colorectal cancer and identifying new therapeutic targets.
Understanding the mechanisms of adipose tissue influence on colorectal cancer may assist in disease prevention and identifying new therapeutic targets.
May inform colorectal cancer prevention strategies via visceral fat modulation; leaves open clinical validation of adipose-derived pathways.
The paper gives the current data available in the literature on the relationship and pathogenetic mechanisms of influence of adipose tissue on colorectal carcinogenesis. It considers the aspects of changes in adipose tissue and microenvironment of the tumor itself, including those under the influence of biologically active substances secreted by adipocytes; differences in subcutaneous and visceral fat and their importance in the development and progression of colorectal cancer (CRC), as well as the role of adipose tissue-derived stem cells. Understanding these mechanisms for adipose tissue influence on CRC will assist not only in preventing this disease, but also in searching for new therapeutic targets.
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Moskalenko et al. (2019) conducted a review in Colorectal cancer. Adipose tissue was evaluated. Adipose tissue and its microenvironment, including differences in subcutaneous and visceral fat, play a pathogenetic role in the development and progression of colorectal cancer.
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