Key result
Oral ibuprofen suspensions reach osmolality up to ~4222 mOsm/kg, raising enteral concerns in preterm infants.
Why the study?
The osmolality of commercially available oral ibuprofen suspensions used for PDA treatment in preterm infants is not well known, raising concerns about potential gastrointestinal adverse effects.
Commercially available oral ibuprofen suspensions have extremely high osmolality, raising significant safety concerns regarding their enteral use for patent ductus arteriosus closure in preterm infants.
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May support oral ibuprofen for preterm PDA; leaves open need for RCTs to confirm efficacy and safety before practice change.
Pereira‐da‐Silva et al. (2008) conducted a letter in Patent ductus arteriosus. Oral ibuprofen suspensions was evaluated on Osmolality. Commercially available oral ibuprofen suspensions have high osmolality ranging from 1495.0 to 4221.7 mOsm/kg, raising concerns about their enteral use and potential adverse effects in preterm infants.
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