Key result
Cooled peritoneal dialysate reduces myocardial blood flow heterogeneity by ~14% vs normothermic dialysis.
Why the study?
Moderate therapeutic hypothermia is cardioprotective, and peritoneal dialysis offers an opportunity to deliver it, but its cardiac perfusion consequences and associated arrhythmic risk needed investigation.
Does therapeutic hypothermia via cooled peritoneal dialysate reduce myocardial blood flow heterogeneity and simulated arrhythmic risk in patients undergoing peritoneal dialysis?
Population
7 PD patients
Comparison
Cooled peritoneal dialysate at 32°C vs usual PD regimen
Authors
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Cooled PD dialysate may lower perfusion heterogeneity and simulated arrhythmia risk in PD patients; leaves open clinical translation pending larger trials.
Does therapeutic hypothermia via cooled peritoneal dialysate reduce myocardial blood flow heterogeneity and simulated arrhythmic risk in patients undergoing peritoneal dialysis?
Effect estimate: -14%
p-value: p=0.03
Therapeutic hypothermia delivered via peritoneal dialysis reduces myocardial perfusion heterogeneity and simulated risk of ventricular arrhythmias.
Kharche et al. (2021) studied End-stage renal disease on peritoneal dialysis (n=7). Cooled peritoneal dialysate vs. Normothermic peritoneal dialysate (37 °C) was evaluated on Myocardial blood flow heterogeneity at rest (-14%, p=0.03). Therapeutic hypothermia using cooled peritoneal dialysate significantly reduced myocardial blood flow heterogeneity by 14% at rest and after stress compared to normothermic dialysis.
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