Key result
LMWH prevents hemodialysis circuit clotting while causing less bleeding and thrombocytopenia than UFH.
Why the study?
Unfractionated heparin has variable biological activity risking under and over anticoagulation, motivating the development of low molecular weight heparins for hemodialysis.
Do low molecular weight heparins improve reliability and safety compared to unfractionated heparin in patients undergoing hemodialysis?
Population
Patients undergoing hemodialysis
Comparison
Low molecular weight heparins vs unfractionated heparin
Design
Review
Authors
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LMWHs may reduce bleeding versus UFH in hemodialysis; leaves open need for contemporary randomized confirmation.
Do low molecular weight heparins improve reliability and safety compared to unfractionated heparin in patients undergoing hemodialysis?
LMWHs offer a more reliable and safer anticoagulation alternative to UFH for routine outpatient hemodialysis.
Andrew Davenport (2013) conducted a review in Hemodialysis. Low molecular weight heparins (LMWHs) vs. Unfractionated heparin (UFH) was evaluated. Low molecular weight heparins are effective in preventing extracorporeal circuit clotting during hemodialysis and are safer with fewer bleeding episodes and less thrombocytopenia than UFH.
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