Key result
Low-molecular-weight heparin was not associated with a higher risk of total bleeding compared with unfractionated heparin in hemodialysis patients (HR 0.90; 95% CI 0.72-1.14).
Why the study?
Does low-molecular-weight heparin increase the risk of bleeding compared to unfractionated heparin in chronic hemodialysis patients?
Population
5322 prevalent and incident patients with chronic hemodialysis from 21 centers in Québec, Canada.
Comparison
Low-molecular-weight heparin for extracorporeal… vs Unfractionated heparin for extracorporeal…
Design
Cohort
Authors
Loading...
Does not support changing heparin type for bleeding risk in HD; leaves open need for randomized confirmation.
Cohort (n=5,322)
Yes
Does low-molecular-weight heparin increase the risk of bleeding compared to unfractionated heparin in chronic hemodialysis patients?
Hazard Ratio: 0.9 (95% CI 0.72–1.14)
LMWH does not increase the risk of bleeding compared with UFH for extracorporeal circuit anticoagulation in hemodialysis patients, supporting its safety as a convenient alternative.
Lazrak et al. (2018) conducted a cohort in Chronic hemodialysis (n=5,322). Low-molecular-weight heparin (LMWH) vs. Unfractionated heparin (UFH) was evaluated on Total bleeding (HR 0.90, 95% CI 0.72-1.14). Low-molecular-weight heparin was not associated with a higher risk of total bleeding compared with unfractionated heparin in hemodialysis patients (HR 0.90; 95% CI 0.72-1.14).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: