Key result
Unfractionated heparin shows similar bleed-free survival compared to LMWH in hemodialysis patients.
Why the study?
Does low molecular weight heparin compared to unfractionated heparin reduce major bleeding in hemodialysis patients?
Population
1,411 hemodialysis patients requiring circuit anticoagulation (522 in UFH cohort, 889 in LMWH cohort)
Comparison
Low molecular weight heparin for anticoagulation… vs Unfractionated heparin for anticoagulation of…
Design
Cohort
Follow-up
792 patient-years of exposure for UFH and 1,200…
Authors
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Retrospective data on major bleeding with LMWH versus UFH in HD leave optimal circuit anticoagulation open; prospective RCTs needed.
Observational (n=1,411)
No
Does low molecular weight heparin compared to unfractionated heparin reduce major bleeding in hemodialysis patients?
Odds Ratio: 0.904 (95% CI 0.557–1.468)
Absolute Event Rate: 1.33% vs 1.92%
p-value: p=0.684
Low molecular weight heparin and unfractionated heparin have similar safety profiles regarding major bleeding when used for extracorporeal anticoagulation in hemodialysis patients.
Nadarajah et al. (2015) conducted an observational in Hemodialysis (n=1,411). Unfractionated heparin (UFH) vs. Low molecular weight heparin (LMWH) was evaluated on Major bleeding event (ISTH definition) (OR 0.904, 95% CI 0.557-1.468, p=0.684). Unfractionated heparin was associated with similar bleed-free survival compared to low molecular weight heparin in hemodialysis patients (OR 0.904; 95% CI 0.557-1.468; p=0.684).
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