Key result
Lung transplant recipients show ~73% lower CMV-specific T-cell frequencies than controls, correlating with increased infections.
Why the study?
Do CMV-specific T-cell levels differ among kidney, heart, and lung transplant recipients and correlate with CMV infection susceptibility?
Observational (n=156)
Do CMV-specific T-cell levels differ among kidney, heart, and lung transplant recipients and correlate with CMV infection susceptibility?
Absolute Event Rate: 0.5% vs 1.82%
Monitoring CMV-specific CD4 T cells may help assess long-term susceptibility to CMV infections, particularly in lung transplant recipients who show significantly lower T-cell reactivity.
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May stratify CMV infection risk in transplant recipients; hypothesis-generating and requires prospective validation.
Sester et al. (2005) conducted an observational in Kidney, heart and lung transplantation (n=156). Lung transplantation vs. Healthy controls was evaluated on Median CMV-specific T-cell frequencies. Lung transplant recipients had significantly lower median CMV-specific T-cell frequencies (0.50%) compared to healthy controls (1.82%), correlating with infectious episodes (r=-0.57, p=0.005).
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