Key result
Anti-IL-22 neutralizing antibodies boost survival to ~80% and reduce inflammatory lesions in EV71-infected mice.
Why the study?
Hand, foot, and mouth disease can cause fatal encephalitis in young children, but there is no effective antiviral drug available to treat it when caused by enterovirus 71.
Answers are grounded in this paper and cite their sources.
Hand, foot, and mouth disease (HFMD) can cause fatal encephalitis in 0-5-year-old infants and children. There is no effective antiviral drug available to treat HFMD caused by enterovirus 71 (EV71). Our study investigates the relationship between levels of IL-22 expression and the severity of disease after EV71 infection in a mouse model. Anti-IL-22 neutralizing antibodies were tested in EV71-infected mice of different ages. Our results show that anti-IL-22 neutralizing antibodies can effectively reduce mortality in EV71-infected mice. Anti-IL-22 neutralizing antibody effectively reduced various EV71-associated symptoms indicating promising potential of this therapeutic effector in patients with EV71-associated HFMD.
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Zhang et al. (2023) studied Enterovirus 71 (EV71) infection (n=20). Anti-IL-22 neutralizing antibody vs. PBS was evaluated on Survival rate (p=<0.05). Anti-IL-22 neutralizing antibodies significantly increased the survival rate to 80% compared to 0% in PBS-treated controls and reduced inflammatory lesions in EV71-infected mice.
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