Key result
Del Nido cardioplegia linked to ~136% greater risk of postoperative tachyarrhythmias.
Why the study?
Postoperative tachyarrhythmias are a significant complication following pediatric congenital heart surgery, and this study aimed to determine if surgical and perioperative improvements have mitigated these risks.
Population
385 pediatric patients under 18 years undergoing elective surgery for VSD and/or RVOT obstruction variants
Comparison
Patients who developed postoperative tachyarrhythmias vs those who did not
Design
Retrospective cohort study
Authors
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May warrant arrhythmia vigilance with del Nido in pediatric cases; hypothesis-generating and requires prospective validation.
Cohort (n=385)
No
Odds Ratio: 2.36 (95% CI 1.01–5.52)
p-value: p=0.047
Postoperative tachyarrhythmias remain a significant complication in pediatric congenital heart surgery, particularly in younger patients, those with prolonged cardiopulmonary bypass, and those receiving del Nido cardioplegia.
Lapmahapaisan et al. (2025) conducted a cohort in Congenital heart disease (VSD and/or RVOT obstruction) (n=385). del Nido cardioplegia was evaluated on Incidence and risk factors of postoperative tachyarrhythmias (OR 2.36, 95% CI 1.01-5.52, p=0.047). Del Nido cardioplegia (OR 2.36; 95% CI 1.01-5.52), prolonged CPB duration, and younger age were identified as independent risk factors for postoperative tachyarrhythmias (12.7% overall incidence).
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