Key result
NAFLD linked to abnormal expression of ~3,200 lncRNAs and mRNAs versus normal liver tissue.
Why the study?
The characteristics of long non-coding RNA expression in non-alcoholic fatty liver disease were not well characterized.
Case-Control (n=10)
Answers are grounded in this paper and cite their sources.
Significant differences in lncRNA expression exist between NAFLD and normal liver tissues, suggesting a potential role in NAFLD pathogenesis.
OBJECTIVE: To analyze the characteristics of long non-coding RNA (lncRNA) expression in non-alcoholic fatty liver disease (NAFLD). Methods: lncRNA-mRNA microarray was conducted on the liver tissue samples from 10 patients with simple gallbladder stone (5 NAFLD liver samples and 5 normal liver samples), and the differentially expressed lncRNA was analyzed by bioinformatics technology. Results: Compared with the normal liver samples, there were abnormal expression of 1 735 lncRNAs and 1 485 mRNAs in NAFLD liver samples. Among them, 535 lncRNAs and 760 mRNAs were up-regulated, 1 200 lncRNAs and 725 mRNAs were down-regulated. Conclusion: Compared with normal liver, the expression of lncRNA in NAFLD tissues is obviously abnormal. These lncRNAs may play an important role in the occurrence and development of NAFLD.
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Sun et al. (2017) conducted a case-control in Non-alcoholic fatty liver disease (n=10). Non-alcoholic fatty liver disease vs. Normal liver was evaluated on Differentially expressed lncRNAs and mRNAs. Non-alcoholic fatty liver disease was associated with the abnormal expression of 1,735 lncRNAs and 1,485 mRNAs compared to normal liver tissue.
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