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October 25, 2007Biochemical Society Transactions

Mitochondrial protein kinase Cϵ (PKCϵ): emerging role in cardiac protection from ischaemic damage

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Key result

Mitochondrial PKCϵ signaling mediates cardioprotection against ischemia-reperfusion injury.

Population

Preclinical models of cardiac ischaemia/reperfusion injury

Design

Review

Authors

GBGrant R. BudasGilead Sciences (United States)DMDaria Mochly‐RosenHeart Failure & Transplant

Discussion

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Implication

May guide mitochondrially targeted cardioprotection research; leaves open clinical translation pending prospective trials.

Structured PICO

P
Population
Preclinical models of cardiac ischaemia/reperfusion injury
E
Exposure
Mitochondrial protein kinase C epsilon (PKCε) signaling
O
Outcome
Cardioprotection from ischaemia/reperfusion damage

This review highlights the emerging role of mitochondrial PKCε and its targets in protecting the heart from ischemia/reperfusion injury.

Cite This Study

Budas et al. (2007) conducted a review in Cardiac ischaemia/reperfusion injury. Protein kinase C epsilon (PKCϵ) was evaluated. Protein kinase C epsilon (PKCϵ) plays a critical role in cardioprotective signaling pathways at the mitochondria to protect the heart from ischemia/reperfusion injury.

synapsesocial.com/papers/6aa8e3f116a2a0577c6bf751https://doi.org/10.1042/bst0351052
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