Population
Isolated mitochondria from heart, liver, and brain
Design
Preclinical
Authors
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May guide cardioprotection research; leaves open translation of PKG-mitoKATP signaling to clinical therapies.
PKG acts as the terminal cytosolic component of the trigger pathway for cardioprotection, transmitting signals to the inner mitochondrial membrane via a pathway involving PKC-epsilon.
Costa et al. (2005) studied this question.
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