Augmentation index and arterial stiffness in patients with type 2 diabetes mellitus
View Full Paper
Ask AI
Bookmark
Share
Key result
T2DM is linked to ~13% higher aortic stiffness but no difference in augmentation index.
- P=0.184
- n=106
Why the study?
Patients with type 2 diabetes mellitus have increased arterial stiffness but not increased augmentation index, suggesting different mechanisms contributing to AIx in T2DM compared with healthy individuals.
Does Augmentation index (AIx) correlate with systemic arterial stiffness in patients with type 2 diabetes mellitus compared to controls?
Population
53 patients with type 2 diabetes mellitus and 53 matched controls
Comparison
Patients with type 2 diabetes mellitus vs matched controls
Design
Case-control study
Authors
Discussion
Loading...
Member takes
Implication
AIx should not be used as a stiffness marker in T2DM; leaves open distinct determinants needing prospective validation.
Study Design
Type
Case-Control (n=106)
Multicenter
No
Structured PICO
Does Augmentation index (AIx) correlate with systemic arterial stiffness in patients with type 2 diabetes mellitus compared to controls?
P
Population
106 participants, comprising 53 patients with type 2 diabetes mellitus and 53 age- and sex-matched healthy controls free of clinical cardiovascular disease, assessed in a cross-sectional study.
C
Comparator
Matched controls
O
Outcome
Cardiovascular and clinical determinants of Augmentation index (AIx) and its relationship to arterial stiffnesssurrogate
Main Result
Absolute Event Rate: 27% vs 24%
p-value: p=0.184
Augmentation index is not significantly related to regional large artery stiffness in T2DM patients or controls and should not be used as a surrogate marker for systemic arterial stiffness.
Limitations
- Relatively small case-control comparison study that cannot attribute causality
- Arterial stiffness was determined via PWV only; addition of other markers would strengthen findings
- More than half the patients with T2DM were taking medication for hypertension or hyperlipidaemia, which could have influenced the results
Cite This Study
Climie et al. (2013) conducted a case-control in Type 2 diabetes mellitus (n=106). Type 2 diabetes mellitus vs. Healthy controls was evaluated on Central augmentation index (%) (p=0.184). Patients with type 2 diabetes mellitus had significantly higher aortic stiffness (7.6 vs 6.7 m/s) compared to healthy controls, but no significant difference in augmentation index (27% vs 24%).
View Full Paper
Ask AI
Bookmark
Share