What question did this study set out to answer?

To assess the impact of type 1 diabetes on arterial stiffness and central hemodynamic parameters, potentially influencing cardiovascular mortality.

July 1, 2000QJMOpen Access

Increased augmentation index and systolic stress in type 1 diabetes mellitus

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Why the study?

Is type 1 diabetes mellitus associated with increased augmentation index and systolic stress compared to matched controls?

To assess the impact of type 1 diabetes on arterial stiffness and central hemodynamic parameters, potentially influencing cardiovascular mortality.
Investigated 35 patients with type 1 diabetes and 35 matched controls using pulse wave analysis.
Measured central aortic waveforms to calculate augmentation index (AIx) and tension time index (TTI).
Compared peripheral and central blood pressure between the two groups.
AIx was significantly higher in type 1 diabetes patients (7.1 +/- 1.6%) compared to controls (0.4 +/- 2.0%), p=0.01.
TTI was elevated in diabetic patients (2307 +/- 51 mmHg x s x min(-1)) compared to controls (2010 +/- 61 mmHg x s x min(-1)), p<0.001.
Pulse wave velocity also increased in the diabetic group, indicating higher arterial stiffness.

Is type 1 diabetes mellitus associated with increased augmentation index and systolic stress compared to matched controls?

Population

70 individuals, comprising 35 patients with type 1 diabetes and 35 matched controls

Intervention

Type 1 diabetes mellitus (observational exposure)

Comparator

Matched controls without type 1 diabetes

Outcome

Augmentation index (AIx) and tension time index (TTI)surrogate

Type 1 diabetes is associated with increased systemic arterial stiffness and systolic load, which may contribute to excess cardiovascular risk.

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May explain excess CV risk in type 1 diabetes; hypothesis-generating for stiffness-targeted interventions.

Ian B. Wilkinson (2000) studied this question.

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