Increases in Central Aortic Impedance Precede Alterations in Arterial Stiffness Measures in Type 1 Diabetes
Why the study?
Are central arterial properties altered early in young individuals with type 1 diabetes compared to nondiabetic controls?
Population
17 young individuals with type 1 diabetes and nondiabetic control subjects participating in the Cardio-Diab…
Design
Cross-sectional
Authors
Discussion
Loading...
Member takes
Implication
Early Zc elevation in young type 1 diabetes may indicate preclinical vascular change; leaves open links to microvascular risk and need for longitudinal validation.
Structured PICO
Are central arterial properties altered early in young individuals with type 1 diabetes compared to nondiabetic controls?
P
Population
17 young individuals with type 1 diabetes (mean duration 15.3 +/- 0.7 years) and nondiabetic control subjects participating in the Cardio-Diab Study
C
Comparator
Nondiabetic control subjects
O
Outcome
Aortic characteristic impedance (Zc) and Pulse wave velocity (PWV)surrogate
Aortic characteristic impedance is increased early in type 1 diabetes before changes in pulse wave velocity, suggesting early central arterial alterations that may contribute to microvascular damage.
Cite This Study
Sweitzer et al. (2007) studied this question.