November 1, 2003Journal of Hypertension
Pulse pressure is associated with age and cardiovascular disease in type 1 diabetes
Why the study?
Are mean arterial pressure and pulse pressure associated with incident cardiovascular disease in young individuals with type 1 diabetes?
Population
3,250 individuals with type 1 diabetes from the EURODIAB Prospective Complications Study, mean age 33 years.
Design
Cohort
Follow-up
median 7.4 years
Authors
Discussion
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Member takes
Implication
No association of MAP or PP with incident CVD; leaves open their prognostic role in young type 1 diabetes.
Key Points
- The study aims to investigate the relationship between age, pulse pressure, and cardiovascular disease in individuals with type 1 diabetes.
- Analyzed a cohort of 3250 individuals from the EURODIAB Prospective Complications Study.
- Employed linear regression for assessing age and pulse pressure associations.
- Used Cox regression to estimate relative risks for cardiovascular disease, adjusted for age and other factors.
- Age was significantly associated with pulse pressure (P < 0.001), stronger in individuals with microalbuminuria or retinopathy.
- Relative risk for cardiovascular disease per 10 mmHg increase in mean arterial pressure was 1.08 (0.94-1.24).
- Relative risk for cardiovascular disease per 10 mmHg increase in pulse pressure was 1.09 (0.98-1.21).
Structured PICO
Are mean arterial pressure and pulse pressure associated with incident cardiovascular disease in young individuals with type 1 diabetes?
P
Population
3,250 individuals with type 1 diabetes from the EURODIAB Prospective Complications Study, mean age 33 years.
I
Intervention
Pulse pressure and mean arterial pressure (observational exposure)
O
Outcome
Incident cardiovascular diseasehard clinical
In young individuals with type 1 diabetes, age is associated with increased pulse pressure, especially in the presence of microvascular complications, supporting the concept of early vascular aging.
Cite This Study
Schram et al. (2003) studied this question.