Key result
Elevated pulse pressure independently predicted all-cause mortality (HR 1.2; 95% CI 1.1-1.3 per 10 mmHg increase), cardiovascular events, and end-stage renal disease in Type 1 diabetes.
Why the study?
Do elevated pulse pressure and placental growth factor predict mortality, cardiovascular events, and progression to end-stage renal disease in patients with Type 1 diabetes?
Population
900 patients with Type 1 diabetes (458 with diabetic nephropathy), mean age 44 ± 11 years.
Comparison
Elevated pulse pressure and placental growth… vs Pulse pressure and placental growth factor…
Design
Cohort
Follow-up
median 8 (0-13) years
Authors
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May inform risk stratification in type 1 diabetes; hypothesis-generating and requires prospective trials before practice change.
Cohort (n=900)
Do elevated pulse pressure and placental growth factor predict mortality, cardiovascular events, and progression to end-stage renal disease in patients with Type 1 diabetes?
Hazard Ratio: 1.2 (95% CI 1.1–1.3)
p-value: p=<0.001
Elevated pulse pressure and placental growth factor independently and synergistically predict mortality, cardiovascular events, and end-stage renal disease in patients with Type 1 diabetes.
Theilade et al. (2012) conducted a cohort in Type 1 diabetes (n=900). Elevated pulse pressure vs. Lower pulse pressure was evaluated on All-cause mortality (per 10 mmHg increase in pulse pressure) (HR 1.2, 95% CI 1.1-1.3, p=<0.001). Elevated pulse pressure independently predicted all-cause mortality (HR 1.2; 95% CI 1.1-1.3 per 10 mmHg increase), cardiovascular events, and end-stage renal disease in Type 1 diabetes.
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