Why the study?
Does type 1 diabetes increase arterial stiffness as measured by aortic augmentation index and subendocardial viability ratio compared to healthy controls?
Population
89 subjects with type 1 diabetes and 95 control subjects.
Comparison
Type 1 diabetes (exposure) vs Control subjects without diabetes
Design
Cross-sectional
Authors
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Alerts to possible early vascular changes in type 1 diabetes; leaves open prospective validation of stiffness measures for risk prediction.
Does type 1 diabetes increase arterial stiffness as measured by aortic augmentation index and subendocardial viability ratio compared to healthy controls?
Type 1 diabetes in relatively young individuals is associated with increased central systolic blood pressure and decreased myocardial perfusion relative to cardiac workload, suggesting accelerated arterial stiffening.
Brooks et al. (1999) studied this question.
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