Key result
18F-FDG PET/CT and MDCTA yield positive but weak diagnostic benefit in suspected infective endocarditis.
Why the study?
Sensitivity and specificity of the modified Duke criteria for native valve endocarditis and prosthetic material-related infection are suboptimal, and the diagnostic value of non-invasive imaging modalities is unclear.
Do non-invasive imaging modalities (MDCTA, MRI, PET/CT, scintigraphy) improve the diagnosis of infective endocarditis in adults?
Population
31 studies on adults with suspected native valve endocarditis and prosthetic material-related infection
Comparison
Non-invasive imaging modalities including MDCTA, ECG-gated MRI, 18F-FDG PET/CT, and leucocyte scintigraphy
Design
Systematic literature review according to PRISMA and GRADE criteria
Authors
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Supports inclusion of 18F-FDG PET/CT and MDCTA in suspected infective endocarditis work-up; extends diagnostic evidence synthesis but highlights need for stronger trials.
Systematic Review
Do non-invasive imaging modalities (MDCTA, MRI, PET/CT, scintigraphy) improve the diagnosis of infective endocarditis in adults?
18F-FDG PET/CT and MDCTA provide diagnostic benefit and should be considered in the work-up of suspected infective endocarditis.
Gomes et al. (2016) conducted a systematic review in infective endocarditis. Non-invasive imaging modalities (18F-FDG PET/CT, MDCTA, MRI, leucocyte scintigraphy) was evaluated on diagnostic performance. Non-invasive imaging modalities, particularly 18F-FDG PET/CT and MDCTA, provided positive albeit weak evidence for diagnostic benefit in adults with suspected infective endocarditis.
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