Key result
Advanced imaging techniques, including 18F-FDG-PET and SPECT, improve the diagnostic sensitivity for infective endocarditis, particularly in patients with prosthetic valves and intra-cardiac devices.
Why the study?
Does advanced imaging (18F-FDG-PET, SPECT, 3D-TOE, MSCT) improve diagnostic accuracy for infective endocarditis in high-risk patients compared to conventional techniques?
Does advanced imaging (18F-FDG-PET, SPECT, 3D-TOE, MSCT) improve diagnostic accuracy for infective endocarditis in high-risk patients compared to conventional techniques?
Advanced imaging modalities like 18F-FDG-PET and SPECT significantly improve the diagnostic accuracy of infective endocarditis in patients with prosthetic valves or cardiac devices where conventional criteria fall short.
May support adjunctive 18F-FDG-PET/SPECT in prosthetic/device IE; leaves open prospective validation of diagnostic algorithms.
Infective endocarditis is a heterogeneous condition whose incidence is rising. Despite advances in surgery and diagnostic methods, one-year mortality has not changed and it remains at 30%. Patients with prosthetic valve and intra-cardiac device-related endocarditis are being seen more frequently and this condition is difficult to diagnose with conventional microbiological and imaging techniques. The modified Duke criteria lack sensitivity in this group and should be supplemented with newer imaging techniques, including 18F-fluorodeoxyglucose positron emission tomography (18F-FDG-PET) and single-photon emission computed tomography (SPECT). In this article, we discuss these techniques and their role in the diagnosis of infective endocarditis.
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Harding et al. (2018) conducted a review in Infective endocarditis. Advanced imaging techniques (18F-FDG-PET, SPECT, MSCT, 3D-TOE) vs. Conventional imaging and modified Duke criteria was evaluated. Advanced imaging techniques, including 18F-FDG-PET and SPECT, improve the diagnostic sensitivity for infective endocarditis, particularly in patients with prosthetic valves and intra-cardiac devices.
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