January 25, 2013Journal of Cardiovascular Electrophysiology
Fascicular and Nonfascicular Left Ventricular Tachycardias in the Young: An International Multicenter Study
Key result
Pediatric nonfascicular left VT is linked to an ~9% sudden death rate versus fascicular VT.
- P<0.01
- n=152
Population
152 pediatric patients with ventricular tachycardia originating from left heart structures, mean age 10.0 ±…
Design
Cohort
Follow-up
2 years for fascicular VT, 3.5 years for nonfascicular LV VT
Authors
Discussion
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Implication
Nonfascicular VT may identify higher sudden death risk in pediatric LV tachycardia; hypothesis-generating for subtype-specific risk stratification.
Study Design
Type
Cohort (n=152)
Multicenter
Yes
Structured PICO
P
Population
152 pediatric patients (mean age 10.0 years, 62% male) with fascicular or nonfascicular left ventricular tachycardia and normal or minor structural heart abnormalities, followed for 2 to 3.5 years.
E
Exposure
Medical therapy (adenosine, calcium channel blockers, various antiarrhythmics) and catheter ablation
O
Outcome
Clinical presentation, treatment efficacy (tachycardia termination, recurrence, ablation success), and long-term outcomes (freedom from arrhythmias, mortality)
Main Result
Absolute Event Rate: 0% vs 8.7%
p-value: p=<0.01
In pediatric patients with left ventricular tachycardias, catheter ablation is often curative, though nonfascicular LV VT carries a higher risk of sudden death compared to fascicular VT.
Cite This Study
Collins et al. (2013) conducted a cohort in Pediatric ventricular tachycardia originating from left heart structures (n=152). Fascicular left ventricular tachycardia vs. Nonfascicular left ventricular tachycardia was evaluated on Sudden death (p=<0.01). In pediatric patients with left ventricular tachycardia, nonfascicular VT was associated with a higher rate of sudden death compared to fascicular VT (8.7% vs 0%; P<0.01).