Key result
Plasma ANF levels strongly correlate with mean pulmonary artery pressure and PCWP.
Why the study?
The role of atrial natriuretic peptides ANF (1-98) and ANF (99-126) as diagnostic markers of atrial distension in patients with cardiac disease was evaluated.
Do plasma levels of ANF (1-98) and ANF (99-126) correlate with cardiopulmonary hemodynamics and atrial distension in patients with chronic heart disease?
Population
47 patients with chronic ischaemic and/or left sided valvular heart disease
Comparison
Plasma levels of ANF (1-98) vs ANF (99-126) peptides
Design
Observational study with diagnostic right heart catheterization and echocardiography
Authors
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Supports ANF fragments as potential noninvasive hemodynamic markers; cross-sectional data leave clinical utility unproven in chronic heart disease.
Observational (n=47)
Do plasma levels of ANF (1-98) and ANF (99-126) correlate with cardiopulmonary hemodynamics and atrial distension in patients with chronic heart disease?
Effect estimate: r=0.69 to 0.75
p-value: p=<0.0001
Plasma levels of ANF (1-98) and ANF (99-126) are equally good indicators of atrial distension and correlate closely with cardiopulmonary hemodynamics in patients with chronic heart disease.
Mathisen et al. (1993) conducted an observational in Chronic ischaemic and/or left sided valvular heart disease (n=47). Plasma levels of ANF (1-98) and ANF (99-126) was evaluated on Correlation with mean pulmonary artery pressure (r=0.69 to 0.75, p=<0.0001). Plasma levels of ANF (1-98) and ANF (99-126) strongly correlated with mean pulmonary artery pressure (r=0.68-0.75, p<0.0001) and mean pulmonary capillary wedge pressure (r=0.64-0.72, p<0.0001).
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