Key result
Higher T3 in hyperthyroidism is linked to a reduced nocturnal SBP fall.
Why the study?
The modulation of circadian variation of blood pressure and heart rate by excess thyroid hormone in hyperthyroidism was not fully characterized.
Does hyperthyroidism alter the circadian variation of blood pressure and heart rate compared to normal subjects and hypertensive patients?
Cross-Sectional (n=54)
Yes
Does hyperthyroidism alter the circadian variation of blood pressure and heart rate compared to normal subjects and hypertensive patients?
Excess thyroid hormone in severe hyperthyroidism blunts the normal nocturnal fall in blood pressure, highlighting a potential secondary cause of non-dipping blood pressure patterns.
Answers are grounded in this paper and cite their sources.
May flag hyperthyroidism as a reversible non-dipping contributor; hypothesis-generating and requires prospective validation before practice change.
MINAMI, N., IMAI, Y., ABE, K., MUNAKATA, M., SAKURADA, T., YAMAMOTO, M., YOSHIDA, K., SEKINO, H. and YOSHINAGA, K. The Circadian Variation of Blood Pressure and Heart Rate in Patients with Hyperthyroidism. Tohoku J. Exp. Med., 1989, 159 (3), 185-193-The circadian variation of blood pressure (BP) and heart rate (HR) was examined in 18 normal subjects, 15 patients with essential hypertension treated with β-blockers and 21 patients with hyperthyroidism. Most of the patients with hyperthyroidism were also treated with β-blockers. The 24 hr BP was measured with an ambulatory blood pressure monitoring device (UBP-100) every 5min. A nocturnal fall in BP and HR was observed in the patients with essential hypertension treated with β-blockers and the patients with mild to moderate hyperthyroidism as well as normal subjects. On the other hand, in patients with severe hyperthyroidism the nocturnal fall was observed in HR alone, and the fall was small in its amplitude. There was a significant negative correlation between triiodothyronine (T3) level and percentage amplitude of the nocturnal fall in systolic BP (n=21, r=-0.5, p<0.01). However, this relation was not significant in diastolic BP and HR. These results indicate that excess thyroid hormone may modulate the circadian variation of BP and HR.
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Minami et al. (1989) conducted a cross-sectional in Hyperthyroidism (n=54). Hyperthyroidism (elevated T3 levels) vs. Normotensive subjects and essential hypertension patients was evaluated on Correlation between triiodothyronine (T3) level and percentage amplitude of the nocturnal fall in systolic blood pressure (r = -0.5, p=<0.01). In patients with hyperthyroidism, higher triiodothyronine (T3) levels were correlated with a reduced percentage amplitude of the nocturnal fall in systolic blood pressure.
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