Key result
Activating protein kinase C with DOG reduces myocyte death ~18% during simulated ischemia and reperfusion.
Population
Isolated adult rat ventricular myocytes
Comparison
1,2-dioctanoyl-sn-glycerol treatment for 10… vs Untreated myocytes
Design
Preclinical
Authors
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May inform PKC-ε targeting to limit myocyte death in ischemia; leaves open translation beyond isolated rat cells.
Absolute Event Rate: 47.3% vs 57.9%
p-value: p=< 0.05
Activation of PKC-epsilon reduces SR Ca2+ content through phospholamban dephosphorylation, providing a potential mechanism for PKC-mediated cardioprotection during ischemia.
Yamamura et al. (2005) studied Simulated ischemia and reperfusion. 1,2-dioctanoyl-sn-glycerol (DOG) vs. Untreated myocytes was evaluated on Cell death (p=< 0.05). Activation of protein kinase C with 1,2-dioctanoyl-sn-glycerol (DOG) reduced cell death compared to untreated myocytes (47.3% vs 57.9%, P<0.05) during simulated ischemia and reperfusion.
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