Key result
Thymopoietin radioimmunoassay detects levels above 5 ng/ml, requiring Bolton-Hunter labeling to preserve immunoreactivity.
Why the study?
A sensitive radioimmunoassay for thymopoietin was needed to detect concentrations greater than 5 ng/ml.
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Design
Development of a radioimmunoassay using 125I-labeled thymopoietin by the Bolton-Hunter method
Answers are grounded in this paper and cite their sources.
Supports thymopoietin quantification in research; leaves open clinical diagnostic applications pending validation.
A radioimmunoassay for thymopoietin was developed that detects thymopoietin concentrations greater than 5 ng/ml. A critical point in development of the radioimmunossay was preparation of 125I-labeled thymopoietin by the Bolton-Hunter method, since direct iodination of tyrosyl residues impaired the immunoreactivity of thymopoietin.
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Gideon Goldstein (1976) studied this question. A developed radioimmunoassay for thymopoietin detects concentrations greater than 5 ng/ml, requiring 125I-labeling by the Bolton-Hunter method to preserve immunoreactivity.
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