Key result
General anesthesia over 3 hours linked to altered brain development in young children and third-trimester fetuses.
Why the study?
The FDA issued a warning about potential risks of repeated or lengthy general anesthesia in children younger than 3 years and pregnant women, necessitating understanding of the evidence behind this guidance.
Does repeated or lengthy use of general anesthetic and sedation drugs affect brain development in children younger than 3 years or pregnant women in their third trimester?
Population
Children younger than 3 years and pregnant women during their third trimester
Comparison
Repeated or lengthy general anesthesia versus no or shorter anesthesia exposure
Design
Review of preclinical and clinical data
Authors
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FDA warning urges balancing anesthesia benefits vs neurodevelopmental risks in young children; level 5 evidence leaves practice implications open pending prospective data.
Does repeated or lengthy use of general anesthetic and sedation drugs affect brain development in children younger than 3 years or pregnant women in their third trimester?
This review summarizes the evidence behind the FDA warning regarding the potential neurodevelopmental risks of prolonged or repeated general anesthesia in children under 3 years and pregnant women.
Derderian et al. (2017) conducted a review in General anesthesia in children younger than 3 years and pregnant women. General anesthetic and sedation drugs was evaluated on Brain development. Repeated or lengthy use (>3 hours) of general anesthesia in children <3 years or pregnant women in their third trimester may affect children's brain development.
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