Vitamin D Supplementation in Patients with Iron Deficiency Anaemia: A Systematic Review and a Meta-Analysis

Recent studies exhibit low Vitamin D levels and iron deficiency anemia condition co-exist, but evidence on the impact of vitamin D supplementation on iron deficiency anemia is lacking. The objectives of the review were to estimate the efficacy of vitamin D supplementation on patients with iron deficiency anemia. This review included the Randomized Controlled Trials from PubMed, IndMed and Cochrane Database of Systematic Reviews. Trials presenting vitamin D supplementation with control groups administered placebo and published in a peer-reviewed journal were considered eligible. Four trials were included for the primary outcome analysis. Vitamin D supplementation had no statistically significant impact on the outcomes of Hemoglobin {p< 0.18; I2: 36%; MD -0.05, 95% confidence interval (CI) -0.39 to 0.28} and Serum Ferritin {p< 0.18; I2: 36%; MD -0.05, 95% confidence interval (CI) -0.39 to 0.28} However, there was a statistically significant impact for serum Vitamin D levels by supplementation of vitamin D {p