The Effect of MTHFR Gene C677t Polymorphism on the Diagnosis of St-Elevation Myocardial Infarction

The study protocol was reviewed and approved by the Human Research Ethics Committees (Project No. CVRC-971 and Ethic code: IR.AJUMS.REC.1397.597). ambient SCIENCEDiverse studies have attempted to identify the association between Methylenetetrahydrofolate Reductase (MTHFR) gene C677T polymorphism and myocardial infarction (MI) which finally remain inconclusive.We aimed to investigate the possible associations between C677T polymorphism and ST-elevation myocardial infarction (STEMI).Study was conducted by considering case-control as 78 patients with STEMI and 77 other participants with no cardiovascular disease (CVD), ages 30 and higher.A polymerase chain reaction-restriction fragment length polymorphism assay (PCR-RFLP) was performed to determine the C677T polymorphism in all participants.Moreover, a questionnaire was used to assess the demographic and clinical characteristics of all participants.This study showed no significant relationship between MTHFR gene C677T polymorphism and STEMI.However, a highly signi?cant association was also evidenced in between this type of mutation and hypertension.The results of this study showed no significant relationship between MTHFR gene C677T mutation and MI risk.But the MTHFR gene C677T mutation polymorphism showed a significant relationship with hypertension.