OBJECTIVE: This study investigated the patterns of expression of cyclin E in clear cell carcinoma and other gynecological cancers. METHODS: Immunohistochemistry was performed on paraffin-embedded archival specimens of ovarian, endometrial, cervical, and renal carcinomas. RESULTS: Expression of cyclin E was evident in epithelial ovarian carcinomas utilizing immunohistochemistry. Immunohistochemistry revealed a high level of expression of cyclin E in a subset of gynecologic carcinomas, namely clear cell carcinomas, but not in clear cell carcinomas of renal origin. CONCLUSION: These data suggest that an elevated level of immunohistochemical activity of cyclin E is a property of clear cell carcinomas of Müllerian origin. Immunohistochemistry with anti-cyclin E antibodies may serve as a useful method for diagnosing gynecologic clear cell carcinomas. Future studies are needed to confirm a possible increased activity of cyclin E in clear cell tumors.
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Session et al. (1999) studied this question.
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