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Computational analysis reveals predictable function for nearly two-thirds of 73,500 genes across 31 genomes, highlighting a continuous need for experimental protein characterization.
To assess how automatic function assignment will contribute to genome annotation in the next five years, we have performed an analysis of 31 available genome sequences. An emerging pattern is that function can be predicted for almost two-thirds of the 73,500 genes that were analyzed. Despite progress in computational biology, there will always be a great need for large-scale experimental determination of protein function.
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Iliopoulos et al. (2000) studied this question.
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