Key result
Cardiac rehabilitation is linked to similar SPPB and 6MWT improvements in HF regardless of sex.
Why the study?
Differences between sexes in physical performance and response to exercise are established, but sex-related differences in baseline and post-rehabilitation performance and functional recovery among heart failure patients required assessment.
Does sex impact functional recovery and health status in heart failure patients undergoing cardiac rehabilitation?
Observational (n=114)
Does sex impact functional recovery and health status in heart failure patients undergoing cardiac rehabilitation?
p-value: p=0.09
Cardiac rehabilitation improves functional autonomy and exercise tolerance in both male and female heart failure patients, though subjective perception of health status and baseline strength differ by sex.
Background Scientific research has now amply demonstrated the existence of differences between sexes in the context of different areas of exercise, in terms of physical performance, response and adaptation to exercise. Purpose This study aimed to assess sex–related differences in baseline and post–rehabilitation test performance among patients with heart failure, and to determine the impact of sex on health status and functional recovery. Methods The population examined comprised a total of 114 patients, 34 women (age 76.8±10.5) and 80 men (68.2±13.1). On admission and discharge, the two samples were subjected to the following assessment tests: Short Physical Performance Battery, 6 Minutes Walking Test, EuroQol VAS and Handgrip. The intake included two rehabilitation activities in the gym during the day: the first was a moderate intensity aerobic workout and the second were respiratory exercises, stretching, coordination and balance exercises. Results The results show that the total SPPB improved significantly over time in both sexes (p=0.0002), with no statistically significant differences between sexes(p=0.09). For the 6MWT, there are statistically significant improvements between the initial and final tests in both sexes(p‹0.0001), while no statistically significant differences emerge between sexes(p=0.54). In contrast, for the subjective perception of health status, the difference is statistically significant both over time for both sexes(p‹0.0001) and between sexes (p=0.005). Finally, for Handgrip (bilaterally), no clinical or statistical improvements are observed over time in either sex. However, a significant difference emerges between sexes (p‹0.0001), with both initial and final values in men being twice those of women (Table 1). Discussion Cardiac rehabilitation improved functional autonomy, motor performance, and exercise tolerance in both sexes, as indicated by gains in 6MWT and total SPPB scores. In contrast, the sit–to–stand and Handgrip tests showed no clinically or statistically meaningful improvement. Women’s perceived quality of life remained largely unchanged, suggesting the influence of external factors. Additionally, the number of patients able to complete the assessments differed between admission and discharge, representing a clinically relevant finding. Conclusion Despite overall improvements, upper and lower limb muscle strength did not increase significantly, indicating the need for more targeted rehabilitation interventions for both sexes.Table 1
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Monina et al. (2026) conducted an observational in heart failure (n=114). Female sex vs. Male sex was evaluated on Difference in total Short Physical Performance Battery (SPPB) improvement between sexes (p=0.09). Cardiologic rehabilitation significantly improved total SPPB (p=0.0002) and 6MWT (p<0.0001) in heart failure patients, with no statistically significant differences in functional recovery between sexes.
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