What is the clinical evidence from this study?

Study design: Case Report. Population: AA amyloidosis with acute heart failure (n=1). Intervention: Advanced echocardiography and cardiac magnetic resonance.

What does this research mean for the field?

Comprehensive cardiac phenotyping using advanced echocardiography and cardiac magnetic resonance can identify rare cardiac involvement in AA amyloidosis, serving as a crucial diagnostic clue for previously unrecognized systemic disease. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To describe the presentation and diagnostic evaluation of rare cardiac involvement in amyloid A amyloidosis in a patient with end-stage renal disease.

September 15, 2026European Heart Journal Supplements

The Heart as a Diagnostic Clue to Amyloid a Amyloidosis

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Key result

Advanced echo and CMR detect cardiac involvement to diagnose previously unrecognized systemic AA amyloidosis.

Population

A 64-year-old woman with acute heart failure and end-stage CKD on hemodialysis

Design

Case report

Follow-up

One month

Authors

GPG PecciPoliclinico Umberto I GMG MarchionniPoliclinico Umberto I MAM AlfaranoPoliclinico Umberto I

Discussion

Member takes

Implication

Advanced imaging may detect rare cardiac AA amyloidosis in ESRD-related HF; hypothesis-generating for targeted screening in inflammatory disease.

Key Points

To describe the presentation and diagnostic evaluation of rare cardiac involvement in amyloid A amyloidosis in a patient with end-stage renal disease.
Diagnostic cardiac workup in a 64-year-old woman with end-stage renal disease presenting with acute heart failure, utilizing electrocardiography, transthoracic echocardiography, and coronary angiography.
Infiltrative cardiomyopathy assessment using cardiac magnetic resonance imaging and confirmation via periumbilical fat pad histological examination.
Echocardiography revealed eccentric left ventricular hypertrophy and severely depressed left ventricular ejection fraction (33%) with marked reduction of global longitudinal strain and apical sparing.
Cardiac magnetic resonance demonstrated meso-subendocardial late gadolinium enhancement, diffuse native T1 elevation, and elevated extracellular volume.
Histological analysis of periumbilical fat tissue identified serum amyloid A deposits, establishing the systemic etiology of the disease.

Study Design

Type

Case Report (n=1)

Structured PICO

Population

A 64-year-old woman with end-stage chronic kidney disease on hemodialysis who presented with acute heart failure and was diagnosed with systemic AA amyloidosis.

Exposure

Diagnostic workup including advanced echocardiography, cardiac magnetic resonance (CMR), and peri-umbilical fat pad biopsy.

Outcome

Diagnosis of serum amyloid A (SAA) amyloidosis with cardiac involvement.

Advanced cardiac imaging (echocardiography and CMR) is pivotal in detecting rare cardiac involvement in AA amyloidosis, which can guide the diagnosis of an underlying systemic inflammatory disorder.

Cite This Study

Pecci et al. (2026) conducted a case report in AA amyloidosis with acute heart failure (n=1). Advanced echocardiography and cardiac magnetic resonance was evaluated. Advanced echocardiography and cardiac magnetic resonance played a pivotal role in detecting cardiac involvement, leading to the diagnosis of previously unrecognized systemic AA amyloidosis.

synapsesocial.com/papers/6aa90187eed42882c1fc1a29 https://doi.org/10.1093/eurheartjsupp/suag058.100

Topics

Heart failure HFrEF treatment Cardiac amyloidosis

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Implication

Advanced imaging may detect rare cardiac AA amyloidosis in ESRD-related HF; hypothesis-generating for targeted screening in inflammatory disease.

The Heart as a Diagnostic Clue to Amyloid a Amyloidosis

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

Topics

The Heart as a Diagnostic Clue to Amyloid a Amyloidosis

Discussion

Member takes

Implication

Key Points

Study Design

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider