What question did this study set out to answer?

To evaluate the antitumor and immunopotentiating efficacy of nonviable microbial structural components and lipid fractions against established tumors.

September 1, 1976Annals of the New York Academy of Sciences

Immunotherapy With Nonviable Microbial Components

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Authors

EREdgar RibiUniversity of Minnesota, Duluth KMK. C. MilnerNational Institutes of Health DGDonald L. GrangerUniversity of Utah

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Implication

Preclinical animal study demonstrates tumor regression following intralesional injection of microbial components combined with trehalose mycolate P3 in guinea pigs, indicating broad immunotherapy...

Key Points

To evaluate the antitumor and immunopotentiating efficacy of nonviable microbial structural components and lipid fractions against established tumors.
Injected microbial components associated with oil droplets suspended in Tween-saline directly into established line 10 tumors in syngeneic guinea pigs.
Tested cell walls from diverse mycobacteria, Escherichia coli, and Salmonella endotoxins with and without the glycolipid fraction P3 (trehalose mycolate).
Nonviable BCG cell walls produced tumor regression and cure rates of 50% to 60%, matching the efficacy of viable BCG, while lipid extraction eliminated potency unless restored by P3.
Adding P3 to cell walls of M. tuberculosis, M. bovis, M. phlei, or M. smegmatis increased cure rates from baseline levels of 20% to 60% up to 90%.
P3 conferred antitumor capability to E. coli cell walls and generated cure rates of up to 93% when combined with endotoxins from rough Re mutant Salmonella.

Cite This Study

Ribi et al. (1976) studied this question.

synapsesocial.com/papers/6aa905b307329764402c837e https://doi.org/10.1111/j.1749-6632.1976.tb41700.x

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Implication

Preclinical animal study demonstrates tumor regression following intralesional injection of microbial components combined with trehalose mycolate P3 in guinea pigs, indicating broad immunotherapy...

Immunotherapy With Nonviable Microbial Components

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Implication

Key Points

Cite This Study

Immunotherapy With Nonviable Microbial Components

Discussion

Member takes

Implication

Key Points

Cite This Study

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