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January 1, 1974JNCI Journal of the National Cancer Institute

Biologically Active Components From Mycobacterial Cell Walls. II. Suppression and Regression of Strain-2 Guinea Pig Hepatoma

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Authors

TMThomas J. MeyerFrederick National Laboratory for Cancer ResearchEREdgar RibiUniversity of Minnesota, DuluthIAIchiro AzumaThe University of Tokyo

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Implication

Preclinical study reveals tumor suppression and regression in strain-2 guinea pigs, indicating cooperation between cell wall skeleton and lipid P3.

Key Points

  • To evaluate the antitumor efficacy of mycobacterial cell wall components, specifically the cell wall skeleton (CWS-I) and the lipid fraction P3, against strain-2 guinea pig hepatoma.
  • Tested the peptidoglycolipid 'cell wall skeleton' (CWS-I) and lipid P3 individually and in combination for tumor suppression and regression in strain-2 guinea pigs with hepatoma.
  • Compared the antitumor activity of isolated fractions against untreated BCG cell walls and tested cured animals for immunity via subsequent tumor rechallenge.
  • CWS-I alone suppressed tumor growth with an efficacy equivalent to untreated BCG cell walls, whereas P3 alone demonstrated no suppressive activity.
  • Regression of established tumors matched untreated BCG cell wall frequencies only when CWS-I was combined with P3.
  • Successful tumor suppression or regression consistently induced systemic immunity against subsequent tumor challenge.

Cite This Study

Meyer et al. (1974) studied this question.

synapsesocial.com/papers/6aa603cfc34c6f6bfa64cbc9https://doi.org/10.1093/jnci/52.1.103
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