Key result
Higher choroidal vascularity index linked to ~20% lower odds of triple vessel CAD.
Why the study?
The study investigated changes in subfoveal choroidal thickness and choroidal vascularity index and their relationship with the severity of coronary artery stenosis in patients with CAD symptoms.
Does choroidal vascularity index correlate with the severity of coronary artery disease in patients undergoing coronary angiography?
Cross-Sectional (n=90)
No
Does choroidal vascularity index correlate with the severity of coronary artery disease in patients undergoing coronary angiography?
Odds Ratio: 0.8 (95% CI 0.7–0.96)
Absolute Event Rate: 0.604% vs 0.625%
p-value: p=0.016
Choroidal vascularity index may serve as a useful non-invasive marker for indicating severe (triple-vessel) coronary artery disease.
Should not yet guide angiography decisions; leaves open choroidal vascularity index as a potential marker for triple-vessel disease severity.
We investigated the changes in subfoveal choroidal thickness and choroidal vascularity index (CVI) and their relationship with the severity of coronary artery stenosis in patients with cardiovascular risk factors and symptoms suggestive of coronary artery disease (CAD). Ninety patients who underwent coronary angiography (CAG) for evaluation of their coronary artery status and cardiac symptoms were included. Forty-two patients showed no evidence of CAD; 31 patients had one to two vessel disease; and 17 had a triple vessel disease. There were no significant differences in the subfoveal choroidal thickness among the three groups; however, the CVI in the triple vessel disease group was lower than those in the other groups. The CVI values were good predictors of the presence of triple-vessel disease (p = 0.020). Multivariate logistic regression analysis results revealed that male sex (odds ratio 5.4, p = 0.049), hypertension (odds ratio 4.9, p = 0.017), and CVI (%, odds ratio 0.8, p = 0.016) were significant factors associated with the presence of triple vessel disease. Although CVI may not be a sensitive marker for detecting early changes in the coronary artery, it may be helpful in indicating severe CAD.
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Seo et al. (2022) conducted a cross-sectional in Coronary artery disease (n=90). Choroidal vascularity index vs. No CAD or 1-2 vessel disease was evaluated on Presence of triple vessel disease (OR 0.8, 95% CI 0.7-0.96, p=0.016). A lower choroidal vascularity index was significantly associated with the presence of triple vessel coronary artery disease (OR 0.8, 95% CI 0.7-0.96, p=0.016).
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