Key result
Cathepsin localization in cancer stem and mast cells suggests renin-angiotensin system bypass loops.
Why the study?
The expression and localization of cathepsins B, D, and G in relation to cancer stem cell subpopulations within moderately differentiated oral tongue squamous cell carcinoma were previously uncharacterized.
Observational (n=9)
No
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Supports cathepsin-mediated RAS bypass in tumors; hypothesis-generating and requires validation before clinical consideration.
Featherston et al. (2017) conducted an observational in Moderately differentiated oral tongue squamous cell carcinoma (n=9). Cathepsins B, D, and G expression was evaluated on Expression and localization of cathepsins B, D, and G in relation to cancer stem cell subpopulations. Cathepsins B and D were localized to cancer stem cells within tumor nests and peri-tumoral stroma, while cathepsin G was localized to phenotypic mast cells, suggesting bypass loops for the renin-angiotensin system.
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