Key result
Cathepsins B, D, and G are expressed in moderately differentiated head and neck cutaneous squamous cell carcinoma, with functionally active cathepsins B and D localizing to cancer stem cell subpopulations.
Why the study?
Cancer stem cell subpopulations in moderately differentiated head and neck cutaneous squamous cell carcinoma express RAS components, prompting investigation into their expression of cathepsins B, D, and G.
Observational (n=15)
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Does not support clinical use of cathepsin inhibitors; leaves open their role as CSC targets in head and neck cSCC.
Featherston et al. (2020) conducted an observational in Moderately differentiated head and neck cutaneous squamous cell carcinoma (MDHNcSCC) (n=15). Cathepsins B, D, and G expression was evaluated on Expression and localization of cathepsins B, D, and G in MDHNcSCC tissue samples and cancer stem cell subpopulations. Cathepsins B, D, and G are expressed in moderately differentiated head and neck cutaneous squamous cell carcinoma, with functionally active cathepsins B and D localizing to cancer stem cell subpopulations.
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