Why the study?
Components of the renin-angiotensin system are expressed by cancer stem cells in many cancers, prompting investigation into their expression by cancer stem cell subpopulations in head and neck metastatic malignant melanoma.
Key points are not available for this paper at this time.
Population
20 human head and neck metastatic malignant melanoma tissue samples and derived primary cell lines
Design
Laboratory investigation
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No immediate clinical implications for melanoma; leaves open RAS targeting of CSCs for future study.
Siljee et al. (2020) studied this question.
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