Key result
Renin-angiotensin system components are expressed on putative stem cells within WHO grade I meningioma microvessels.
Why the study?
Given the critical role of the renin-angiotensin system in stem cell biology and tumorigenesis, this study investigated the expression of RAS components on the putative microvascular stem cell population in WHO grade 1 meningioma.
Observational (n=11)
No
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Supports RAS-targeted investigation in meningioma; leaves open functional role and therapeutic relevance of these stem cells.
Shivapathasundram et al. (2019) conducted an observational in WHO Grade I Meningioma (n=11). Expression of renin-angiotensin system components was evaluated on Expression of PRR, ACE, ATIIR1, and ATIIR2 on the putative stem cell population on the microvessels of WHO grade I meningioma. Components of the renin-angiotensin system, including PRR, ACE, ATIIR1, and ATIIR2, are expressed on the putative stem cell population localized to the microvessels of WHO grade I meningioma.
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